In one week, two boys turned a photo of Secretary of State Hillary Clinton checking her BlackBerry into a meme that made it across all forms of media.

After Secretary Clinton submitted her own "Text From Hillary," the creators decided the joke had gone as far as it could.

The anti-cosmetic surgery blog intended to "shine a spotlight" on noses, but it became more than just that. Instead, photoshopping Ninja Turtles onto people's noses became a meme.

After two months, and more than 100 Ninja Turtle noses, the blog encouraged everyone to cherish their noses and then shut down.

The "Fuck Yeah" trend sky-rocketed on the heels of this shark-themed blog. Today, more than one hundred of the fan club blogs are made every day.

The blog ran for four years, but just recently decided that it was time to say farewell, adding, "It's better to burn out than to fade away."

Another genius Photoshop idea: placing Steve Buscemi's eyes on various female celebrities.

Less than 100 posts and two months later, the blog reached its peak and decided to end it.

There is something scary about celebrities without eyebrows — yet you can't look away, which probably explains why this blog became so popular.

There was no explanation as to why the blog stopped publishing; it likely just ran its course.

Mashup Tumblrs are extremely popular. This one in particular combined two popular concepts: Kanye West and Saved by the Bell.

The blog posted sporadically from 2010 to 2011, yet became fairly popular. Aside from one random post in April 2012, the blog appears to have called it quits.

The "Casually Pepper Spray Everything Cop" became a popular meme after a police officer pepper sprayed student protesters at the University of California Davis during the Occupy movement.

A few months later, the controversy faded and so did the associated Tumblr.

Before Chicks With Steve Buscemi Eyes, a similar Tumblr had some fun with Muppet eyes. The trend even inspired someone to create the opposite: People With Muppet Eyes.

After the most well-known characters were photoshopped, the Tumblr quit.

Ryan Gosling became subject of the "Hey Girl" meme after this Tumblr captioned images, which Gosling was asked to read out loud on television.

This led to Feminist Ryan Gosling and a series of other meta-memes, like Hey Girl, It's Paul Ryan. The original has since called it quits.

This bread-infused Tumblr was so unique, there's really no way to explain it without viewing for yourself.

The joke carried over to the blog Cheese People, but both have since stopped posting.